Direct Targeting of CREB1 with Imperatorin Inhibits TGF β 2‐ERK Signaling to Suppress Esophageal Cancer Metastasis

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

MicroRNA-506 inhibits esophageal cancer cell proliferation via targeting CREB1.

MicroRNAs (miRNAs) act as key regulators of multiple cancers. MicroRNA-506 (miR-506) functions as a tumor suppressor in various types of cancers. However, its role in esophageal cancer remains unclear. In our study, we found that miR-506 was significantly down-regulated in esophageal cancer tissues and cell lines. In vitro assay, our results showed that ectopic over-expression of miR-506 inhibi...

متن کامل

TGF-β signaling in cancer metastasis.

The transforming growth factor (TGF)-β signaling events are well known to control diverse processes and numerous responses, such as cell proliferation, differentiation, apoptosis, and migration. TGF-β signaling plays context-dependent roles in cancer: in pre-malignant cells TGF-β primarily functions as a tumor suppressor, while in the later stages of cancer TGF-β signaling promotes invasion and...

متن کامل

Covalent Targeting of Fgfr/integrin Signaling Inhibits Breast Cancer Metastasis

Cell and molecular biology of breast cancer Faculty abstract(s) 3-4 Cell and molecular biology of breast cancer Graduate Student abstract(s) 5-9 Cell and molecular biology of breast cancer Post-Doctoral/Medical Fellow abstract(s) 10-12 Cell and molecular biology of breast cancer Research Technician abstract(s) 13 Novel modalities or technologies for breast cancer diagnosis and treatment Faculty...

متن کامل

TGF-β Signaling in Cancer.

The transforming growth factor-β (TGF-β) is a family of structurally related proteins that comprises of TGF-β, activins/inhibins, and bone morphogenic proteins (BMPs). Members of the TGF-β family control numerous cellular functions including proliferation, apoptosis, differentiation, epithelial-mesenchymal transition (EMT), and migration. The first identified member, TGF-β is implicated in seve...

متن کامل

Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis

More efficient therapies that target multiple molecular mechanisms are needed for the treatment of incurable bone metastases. Halofuginone is a plant alkaloid-derivative with antiangiogenic and antiproliferative effects. Here we demonstrate that halofuginone is an effective therapy for the treatment of bone metastases, through multiple actions that include inhibition of TGFβ and BMP-signaling. ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Advanced Science

سال: 2020

ISSN: 2198-3844,2198-3844

DOI: 10.1002/advs.202000925